Tuneable Hydrogel Porosity via Dynamic Tailoring of Spinodal Decomposition.

ABSTRACT: Pores within hydrogel structures play a crucial role in fostering cell growth and tissue development. The creation and control of pore size and interconnectivity can be conveniently achieved with aqueous two-phase emulsions. The decomposition of these emulsions into two separate phases can be controlled by carefully choosing the polymer components and solution conditions. Spinodal decomposition, a mechanism of phase separation, can result in a highly interconnected pore morphology, though controlling this process is difficult in practice, limiting its application for in vitro models. Here, a straightforward method is introduced for dynamically halting the phase separation of a gelatin methacryloyl and poly(vinyl alcohol) (GelMA-PVA) polymer blend in the context of a biofabrication process

SUBMITTER: Halwes M 

PROVIDER: S-EPMC12463055 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature