SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c-FOS Expression and Represents a Potential Therapeutic Target.

ABSTRACT: Aberrant alternative splicing plays a crucial role in tumorigenesis. Here, splicing factor 3A subunit 3 (SF3A3) is   significantly upregulated in endometrial cancer (EC) tissues and associated with poor prognosis. Functionally, SF3A3 drives tumor progression by promoting cell proliferation, suppressing apoptosis, and enhancing cisplatin resistance in vitro and in vivo. Mechanistically, SF3A3 regulates alternative splicing of fos proto-oncogene, AP-1 transcription factor subunit (c-FOS), an oncogene linked to chemoresistance, resulting in a ≈2-fold increase in full-length c-FOS expression and activation of downstream anti-apoptotic pathways. Notably, phenylethyl isothiocyanate (PEITC) as a direct inhibitor of SF3A3 through database screening and biophysical validation via surface plasmon re

SUBMITTER: Yu W 

PROVIDER: S-EPMC12463058 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature