Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation.

ABSTRACT: Hormonal mechanisms of fatty liver formation require in-depth exploration, and corresponding therapeutic strategies are urgently needed. Here, through serological testing of mice with fatty liver, it is found that the rhythms of prolactin secretion are disturbed and that the circulating prolactin level is reduced. Based on these findings, prolactin's biological effects on fatty liver are investigated, and biomimetic photothermal-responsive core-shell microneedles with periodically prolactin releasing are proposed to inhibit lipid accumulation in liver. The microneedles are comprised of poly(lactic-co-glycolic acid) shells and prolactin-loaded cores of photothermal black phosphorus, phase-change gelatin, and carrageenan. Under periodically stimulation of near infrared (NIR), the prolactin i

SUBMITTER: Yin H 

PROVIDER: S-EPMC12463070 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature