Structurally Constrained Cyclic (Diacyloxyiodo)Arenes as an Enabling Platform for Hypervalent Iodine(III) Chemistry.

ABSTRACT: Hypervalent iodine(III) chemistry has unlocked remarkable potential in synthetic and catalytic applications over the past decades, yet its development has been constrained by biased thermodynamics between iodine(I) and iodine(III) species, relying on unstable or environmentally unfriendly oxidants and complex electrocatalytic platforms. Here, structurally constrained cyclic (diacyloxyiodo)arenes are presented as a transformative platform to resolve the reactivity/selectivity-generality paradox, enabling one-pot synthesis of diverse hypervalent iodine(III) reagents. The synthetic utility and sustainability of the in situ controlled-release approach are demonstrated through catalytic reactions, asymmetric variations, and biocompatibility studies, including peptide modifications. Central to t

SUBMITTER: Zhong S 

PROVIDER: S-EPMC12463073 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature