Sustainable Electrochemical Strategy for Selective Double Bond Oxidation in the Presence of Aldehyde Groups with Mo─N─O Catalysts.

ABSTRACT: Selective oxidation of double bonds in aldehyde-containing molecules is critical for synthesizing multifunctional organic compounds; however, conventional methods struggle to preserve aldehyde integrity due to competitive over-oxidation. Here, an electrochemical strategy is presented that achieves precise double bond oxidation without aldehyde degradation, using hydroperoxyl radicals (^*OOH) generated by a molybdenum-based catalyst (Mo─N─O). Under mild, energy-efficient conditions (-200 mA), this approach converts cinnamaldehyde to benzaldehyde with complete conversion (100%) and >99% selectivity, outperforming traditional harsh oxidants. Mechanistic analysis reveals that the tailored coordination environment of the catalyst enhances ^*OOH formation, enabling targeted o

SUBMITTER: Li Z 

PROVIDER: S-EPMC12463080 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature