Human placental trophoblast cells express and secrete basigin via a regulated process of extracellular vesicle release.

ABSTRACT:

In brief

The release of basigin protein by human placental trophoblast cells via extracellular vesicle release is a regulated process. This study shows interactions of trophoblast cells with uterine cells during early placental development.

Abstract

Successful pregnancy relies on the regulated invasion of trophoblast cells into the maternal endometrium and subsequent remodeling of spiral arteries. Various factors are involved in regulating these processes, including matrix metalloproteinases (MMPs), cytokines such as interleukins (IL) and transforming growth factor β (TGFβ), and hypoxic conditions. Basigin (BSG), a glycosylated protein, plays an important role in MMP induction and inflammation. The role of BSG during early stages of placental development is not yet clear, no

SUBMITTER: Nabeel MA 

PROVIDER: S-EPMC12463142 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature