Role of weight-adjusted waist circumference index and non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio in prediabetes risk: A mediation analysis.

ABSTRACT:

Objective

This study aims to investigate the prevalence of prediabetes among U.S. adults using NHANES 2017-2023 data, explore the relationship between the weight-adjusted waist circumference index (WWI) and the non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (NHHR) and the risk of prediabetes, and provide a theoretical foundation for the early identification and intervention of prediabetes.

Methods

Logistic regression, linear regression model, subgroup analysis, restricted cubic spline (RCS) analysis, and mediation analysis were employed to examine the effect of WWI on prediabetes and the mediating role of NHHR.

Results

A total of 9,713 adults were included in the analysis, with an age range of 20-80 and a mean age of 51.26 ± 17.25.

SUBMITTER: Mi W 

PROVIDER: S-EPMC12463217 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature