Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening.

ABSTRACT:

Background

Circulating proteins play a critical role in rheumatoid arthritis (RA), yet few have been targeted therapeutically. This study aimed to identify novel protein targets for RA therapy.

Methods

We conducted a comprehensive proteome-wide Mendelian Randomization (MR), colocalization analysis, and summary-data-based MR (SMR) to explore potential causal relationships between plasma proteins and RA, with an overall sample size of 1,148,608. The GWAS data on plasma proteins were obtained from the FinnGen study, the UK Biobank Pharma Proteomics Project and Iceland GWAS data. Then, validation of key molecules' differential expression pattern was done using external transcriptomic data from RA patients, while the Drug Signatures Database (DsigDB) was used to identify potentia

SUBMITTER: Ma Z 

PROVIDER: S-EPMC12463240 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature