High-density LD-based structural variations analysis in ten Native and Mestizo Mexican populations.

ABSTRACT: The main objective of this study was to perform a genome-wide characterization of Structural Variations (SV) based on the deviation of the expected short-range Linkage Disequilibrium (LD) between Single Nucleotide Polymorphisms (SNPs) in 10 Native and Mestizo Mexican populations. We used a panel of 785,663 SNP genotypes, sampled from 383 individuals, of which 71 belonged to ethnic populations and 312 belonged to mestizo populations. The total number of variations found among all populations was 4,375, involving an average of 19,438 SNPs per population, which corresponds to the 3.14% of the total average of SNPs per population. The mean SV size varied from 2,845-8,646 kb across populations (with a mean SV size of 6,161 kb over all populations) and an average of 50.14 SNPs per SV. By groupin

SUBMITTER: Mateos-Valenzuela AG 

PROVIDER: S-EPMC12463268 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature