Blood flow-restricted resistance training modulates miRNAs to improve early hypertensive cardiac function.

ABSTRACT:

Objective

The aim of this study was to explore the differentially expressed miRNAs in the hearts of rats protected from early spontaneous hypertension by blood flow-restricted resistance training and to elucidate the effects of blood flow-restricted resistance training on the expression of these genes.

Methods

Four-week-old SHRs and WKY rats were used and randomly divided into five groups: the normal group (WKY), SHR control group (SHR-SED), high-intensity resistance training group (HIRT), medium-intensity resistance training group (MIRT), and blood flow-restricted medium-intensity resistance training group (BFRT). During the experiment, the body weight, cardiac function and hemodynamic parameters of the rats were measured. After training, total RNA was extracted from the le

SUBMITTER: Tan Z 

PROVIDER: S-EPMC12463276 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature