3D photogrammetry quantifies the size of basal cell carcinoma lesions with submillimeter accuracy: high correlation with lesion response to photodynamic therapy.

ABSTRACT:

Significance

Noninvasive imaging to accurately measure subtle changes in tumor size is underutilized when assessing therapeutic responses in the skin. During photodynamic therapy (PDT) for basal cell carcinoma (BCC), a better definition of the tumor size threshold for PDT responsiveness is needed.

Aim

We aim to quantitatively demonstrate the first clinical evidence of tumor shrinkage after multiple rounds of PDT using a robust measurement and analysis approach.

Approach

Tumors were monitored experimentally using a 3D camera and software system (stereo photogrammetry). A total of 122 BCC tumors in 35 patients were treated with PDT (5-ALA and blue light) in three sessions. Calculated volumes and heights were used to plot changes in tumor size.

Results

In total, 7

SUBMITTER: Maytin EV 

PROVIDER: S-EPMC12463384 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature