Navigating the diagnostic challenges of myoclonus in neurodegenerative disorders: video-EEG/polygraphy, clinical vignettes, and narrative analysis.

ABSTRACT:

Purpose

Myoclonus-sudden, brief, involuntary muscle jerks-is a frequent and diagnostically challenging feature across neurodegenerative disorders. Unlike epileptic myoclonus, these manifestations rarely involve seizures; they often reflect extensive multisystemic pathology (cortical, subcortical, peripheral). Distinguishing neurodegenerative myoclonus from other movement disorders and pinpointing its origin is crucial for accurate diagnosis, prognosis, and tailored management. This narrative analysis explores the diverse phenomenology of myoclonus in neurodegenerative conditions, emphasizing how presentations often differ from typical epileptic myoclonus, which necessitates a nuanced diagnostic approach. We also highlight the indispensable role of video-electroencephalography (vide

SUBMITTER: d'Orsi G 

PROVIDER: S-EPMC12463611 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature