Volume changes in white matter pathways from infancy to early adulthood measured using diffusion tensor based morphometry.

ABSTRACT:

Background

Diffusion tensor imaging (DTI) has proven valuable in assessing structural and architectural features of white matter (WM) in postnatal development. Diffusion tensor-based morphometry (DTBM) uses DTI data to measure local volume changes and has been demonstrated in previous studies to be informative in the evaluation of specific WM pathways in several neurological disorders. In this study, we assess DTBM volume changes during postnatal brain development in typically developing children. In addition, we evaluate in each pathway the relationship between changes in volume and DTI metrics.

Method

We included DTI data from 182 healthy participants in the age range of 0-21 years, from the publicly available database: the NIH Pediatric MRI Data (NIHPD). Data were process

SUBMITTER: Nayak A 

PROVIDER: S-EPMC12463617 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature