Analysis of brain necrosis and secondary cancers after proton beam therapy for pediatric intracranial tumors: a single-center retrospective study.

ABSTRACT:

Background

Proton beam therapy (PBT) is increasingly used for pediatric intracranial tumors due to lower long-term radiation-associated toxicities. However, data on late adverse effects, particularly brain necrosis and intracranial secondary cancer, remain limited. The aim of this study is to evaluate the incidence of these events following PBT in pediatric patients treated at a single center.

Procedure

We retrospectively reviewed the medical records of 189 patients under 20 years of age who received PBT for intracranial tumors between 1991 and 2023. Clinical information, irradiation parameters, concurrent chemotherapy, and follow-up outcomes were collected. Brain necrosis and intracranial secondary cancers were assessed based on events presenting with grade ≥2 clinical symp

SUBMITTER: Mizumoto M 

PROVIDER: S-EPMC12463622 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature