Function value of basement membrane-related genes in odontogenic keratocyst by bioinformatics analysis.

ABSTRACT:

Background

Odontogenic keratocyst (OKC) is an aggressive jaw lesion characterized by high recurrence rates. Disruption of the basement membrane (BM) may contribute to its pathogenesis, through the underlying molecular mechanisms remain incompletely understood.

Methods

Transcriptomic data from 12 non-syndromic OKC and 4 normal oral mucosa (NOM) samples (GSE38494) were analyzed to identify differentially expressed BM-related genes (BM DEGs). Bioinformatics approaches included differential expression analysis, functional enrichment (Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, Gene Set Enrichment Analysis), protein-protein interaction (PPI) network construction, immune infiltration assessment, and validation via single-cell RNA-seq (scRNA-seq; GSE176351). Key finding

SUBMITTER: Yi JR 

PROVIDER: S-EPMC12463645 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature