Evaluating the obesity paradox in patients with sepsis and cancer.

ABSTRACT:

Background

The obesity paradox, where higher body mass index (BMI) is associated with improved survival, is observed in sepsis and cancer individually. However, its effect in patients with both conditions is unclear. The objective of this study is to evaluate the obesity paradox in intensive care unit (ICU) patients with sepsis and cancer and examine whether BMI's impact on mortality varies across patient phenotypes.

Methods

Data from the Medical Information Mart for Intensive Care IV database were analyzed. Patients were categorized by BMI into underweight (<18.5 kg/m², n = 173), normal weight (18.5-24.9 kg/m², n = 1283), overweight (25-29.9 kg/m², n = 1498), and obesity (≥30 kg/m², n = 960). The primary outcome was 28-day mortali

SUBMITTER: Hou C 

PROVIDER: S-EPMC12463649 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature