High fat diet induces gastric production of fibroblast growth factor 23 (FGF23).

ABSTRACT:

Background

A high fat diet (HFD) leads to lesions of the gastric epithelium and causes a proinflammatory environment. Fibroblast growth factor 23 (FGF23), a bone hormone, regulates renal phosphate and vitamin D metabolism. Under pathophysiological conditions production of FGF23 is stimulated. HFD feeding elevates serum FGF23 levels through inflammation.

Objective

We aimed to investigate whether HFD feeding and obesity is associated with gastric FGF23 production.

Methods

Mice were fed a standard diet or HFD for 12 weeks (long-term) or 1 week (short-term), and the stomachs were then examined. Additionally, corpus specimens from patients with obesity, human umbilical vein endothelial cells (HUVECs), and normal human gastric epithelial cells (GES-1) were studied. FGF23 pr

SUBMITTER: Widmayer P 

PROVIDER: S-EPMC12463679 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature