Volumetric Changes in Perianal Fistulizing Crohn's Disease Measured by Magnetic Resonance Is Feasible and Could Be a Potential Biomarker to Predict Clinical Outcomes.

ABSTRACT:

Background and aim

Changes in 3D volumetry of perianal fistulas in patients with Crohn's disease (CD) measured by MRI could be an imaging biomarker of interest. The objective of the study was to determine the value of volumetric changes in CD perianal fistulas after medical treatment to predict outcomes.

Methods

This is a retrospective single-center pilot study evaluating CD patients with active perianal fistulas who started biological therapy between 2012 and 2021. Eligible patients were those who had both pre- and post-treatment pelvic MRI and clinical follow-up of 2-5 years. Patients were categorized as clinically active or in remission based on fistula drainage. Using specific software, we calculated the 3D volume of the fistulas, and their active and fibrotic components

SUBMITTER: Caballol B 

PROVIDER: S-EPMC12463706 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature