Fecal and Serum Metabolome in Crohn's Disease is Linked With Future Flare.

ABSTRACT:

Background

Metabolites are key mediators of various physiological functions. However, there is a lack of data linking their levels to future Crohn's Disease (CD) flares.

Objective

We aimed to identify systemic and gut metabolic changes that precede flare and generate metabolite-based indexes that predict flare using a test cohort, with validation using an independent cohort.

Methods

We analyzed serum and fecal metabolomes in a prospective cohort of patients with quiescent Crohn's Disease monitored until a clinical flare or the end of the study follow-up.

Results

We identified specific metabolic changes in pre-flare samples of Crohn's Disease patients and developed prediction models for a subsequent flare using serum and fecal metabolic signatures. Among the fec

SUBMITTER: Levhar N 

PROVIDER: S-EPMC12463725 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature