Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with alcohol use disorder and liver disease at a liver transplant center.

ABSTRACT:

Background

Phosphatidylethanol (PEth), ethyl glucuronide (EtG), and ethyl sulphate (EtS) are highly sensitive and specific biomarkers of alcohol intake. This study investigated their application and relationship to traditional self-report measures in a mixed cohort of liver disease patients to guide decision making in liver transplant populations.

Methods

We recruited 183 participants (mean age 49.2 years, 62% male), with N = 99 liver disease (88% alcohol-associated liver disease [ALD]), N = 35 alcohol use disorder (AUD), and N = 49 healthy volunteers. Patient-reported alcohol intake and AUDIT score served as references and were compared to traditional biomarkers, PEth and serum EtG/EtS. Receiver operating characteristic (ROC) analysis and a range of biomarker cutoffs were e

SUBMITTER: Watt J 

PROVIDER: S-EPMC12463739 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature