Optimization of ^99mTc-SPECT in the presence of ⁹⁰Y for radioembolization.

ABSTRACT:

Background

^99mTc-macroaggregated albumin (MAA) imaging is part of the standard work-up procedure for radioembolization using ⁹⁰Y microspheres. In certain scenarios, it may be warranted to visualize the distribution of ^99mTc in co-presence of ⁹⁰Y, for example when validating intra-procedural ^99mTc-MAA imaging after ⁹⁰Y-therapy to enable single-session radioembolization. Another instance involves additional ^99mTc-MAA administration during the therapeutic procedure itself, e.g. when initial imaging reveals insufficient targeting of a specific liver segment. In these situations, crosstalk from ⁹⁰Y can result in reduced ^99mTc image quality and quantitative accuracy. This study investigates

SUBMITTER: Kerckhaert CEM 

PROVIDER: S-EPMC12463788 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature