Impact of early PaCO₂ and pH fluctuations on neurological outcomes in ARDS patients receiving VV ECMO: a retrospective cohort study from the CSECLS registry.

ABSTRACT:

Background

Neurological complications significantly contributed to mortality in patients with acute respiratory distress syndrome (ARDS) supported by venovenous extracorporeal membrane oxygenation (VV ECMO). Early fluctuations in arterial partial pressure of carbon dioxide (PaCO₂) during ECMO initiation may have affected cerebral perfusion and increased the risk of brain injury. This study investigated the association between early changes in PaCO₂ and pH levels and subsequent neurological outcomes in patients with ARDS receiving VV ECMO.

Methods

We conducted a retrospective cohort study using data from adult ARDS patients who underwent VV ECMO between January 2018 and December 2022, sourced from the Chinese Society of Extracorporeal Life Support (CSECL

SUBMITTER: Chen X 

PROVIDER: S-EPMC12463811 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature