G6PD deficiency is implicated in Circle of Willis variants in stroke patients and impairs brain vasculature in zebrafish.

ABSTRACT: Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common hereditary enzyme defect in the world, may be involved in cerebrovascular abnormalities suggested by clinical research. However, whether and how G6PD deficiency impairs cerebral vasculature is poorly understood. We therefore aimed at determining the role of G6PD in brain vasculature. By evaluating cerebrovascular imaging data from stroke patients, we found patients with G6PD deficiency exhibited greater morphological variability in the circle of Willis (CoW) with reduced frequency of the anterior communicating artery, bilateral A1 segments, but a higher incidence of fetal posterior cerebral artery (fPCA). To further confirm G6PD deficiency was associated with cerebrovascular abnormalities, we used pharmacological inhibito

SUBMITTER: Cai Y 

PROVIDER: S-EPMC12463879 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature