Mechanical deformations of bone generate interstitial fluid flow at nanoscale velocities around osteocytes.

ABSTRACT: Osteocytes play a critical role in bone mechanobiology, sensing and responding to mechanical loading through fluid flow within the lacunar-canalicular network (LCN). Experimental measurements of interstitial fluid flow in bone are difficult due to the embedded nature of osteocytes in the dense mineralized matrix. Therefore, accurate computer simulations of these processes are essential for understanding bone mechanobiology. Two computational approaches have mostly been used to characterize convective interstitial fluid flow in bone: poroelastic finite element (FE) models, which treat bone as a homogenized porous medium, and fluid-structure interaction (FSI) models, which incorporate explicit LCN microarchitecture. However, these approaches have predicted fluid velocities that differ by thr

SUBMITTER: Munoz A 

PROVIDER: S-EPMC12463924 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature