<i>In silico</i> characterization of chromosomally integrated bla_CTX-M genes among clinical <i>Enterobacteriaceae</i> in Africa: insights from whole-genome analysis.

ABSTRACT: Antimicrobial resistance (AMR) mediated by extended-spectrum β-lactamases (ESBLs) is a growing global concern, particularly among Enterobacteriaceae. The CTX-M-type ESBLs, encoded by the bla _CTX-M gene, are of significant public health importance due to their high prevalence and broad geographic distribution. Typically located on plasmids and often co-occurring with other AMR genes, bla _CTX-M contributes to multidrug resistance (MDR). However, increasing evidence suggests secondary chromosomal integration of bla _CTX-M, sometimes alongside other resistance determinants. The extent and implications of this mechanism remain poorly characterized, especially in Africa, where genomic surveillance is limited. In this study, we re

SUBMITTER: Shawa M 

PROVIDER: S-EPMC12463934 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature