Worldwide patterns and trends in childhood and adolescent brain cancers, 1990-2021: insights from the global burden of disease study 2021.

ABSTRACT:

Background

Childhood and adolescent brain and central nervous system cancers (CABCs) represent the leading cause of cancer-related mortality among individuals aged 0-19 years; however, global trends and socio-demographic disparities remain insufficiently explored.

Methods

We utilized the Global Burden of Disease (GBD) 2021 dataset to evaluate the evolving burden of CABCs across 204 countries from 1990 to 2021. We analyzed age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life years (ASDR) among individuals aged 0-19 years. Methodological approaches, including Joinpoint regression, decomposition analysis, and age-period-cohort modeling, were applied to assess trends

SUBMITTER: Li L 

PROVIDER: S-EPMC12463948 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature