OvaRePred (HerTempo): an enhanced ovarian aging clock for personalized reserve assessment, endocrine age modeling, and predicting reproductive milestones across the female lifecycle.

ABSTRACT:

Background

Women display marked variability in ovarian reserve, which is pivotal for fertility and menopausal timing. Traditional criteria, such as Bologna and Poseidon, classify women into broad groups but do not provide individualized predictions for ovarian aging or reproductive milestones. This study aims to refine the AA model (AMH + age) to enhance clinical usability, robustness, and interpretability.

Materials and methods

Single-center retrospective ART cohort (GnRH-antagonist cycles, 2017-2021). Training: 15,241 cycles (2017-2019); Testing: 14,498 cycles (2020-2021). Poor ovarian response (POR) was defined as <5 oocytes. Three logistic-regression specifications were compared: categorical (Model-0), continuous (Model-1), and polynomial (age quadratic, AMH cubic; Model

SUBMITTER: Xu H 

PROVIDER: S-EPMC12463964 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature