Longitudinal evaluation of T-cell responses to Pfizer-BioNTech and Janssen SARS-CoV-2 vaccines as boosters in Ghanaian adults.

ABSTRACT:

Introduction

In Ghana, at least five different COVID-19 vaccines based on mRNA or adenovirus vector delivery platforms have been authorized by the Ghana Health Service for vaccination. Although these vaccines have been instrumental in the control of COVID-19, data on the longevity of induced immunity in vaccinated individuals in Ghana is limited. This study aimed at assessing the cellular immune response kinetics among Ghanaians receiving booster vaccinations with the mRNA-based Pfizer and adenovirus-based Janssen COVID-19 vaccines.

Methods

We conducted a longitudinal study using 48 Ghanaian adults who had completed primary vaccination series and administered a booster shot with either of the two vaccines. Pre-booster blood samples were collected to serve as the baseline, an

SUBMITTER: Osei F 

PROVIDER: S-EPMC12463971 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature