Impact of nitroglycerin on 28-day mortality in ischemic stroke patients: a retrospective cohort study using the MIMIC-IV database.

ABSTRACT:

Background

The impact of nitroglycerin (NTG) on short-term outcomes in ischemic stroke patients remains unclear. This study aimed to evaluate the association between NTG use-including route, timing, and duration-and 28-day in-hospital mortality.

Methods

We conducted a retrospective cohort study of 3,434 ischemic stroke patients, including 356 who received NTG. Propensity score matching (1:1) was used to reduce confounding. Cox proportional hazards models, Kaplan-Meier analysis, and stratified analyses assessed the association between NTG use and mortality.

Results

NTG use was associated with reduced 28-day mortality before (HR = 0.52, p < 0.001) and after matching (HR = 0.50, p = 0.003). Kaplan-Meier curves confirmed this benefit. Among administration ro

SUBMITTER: Zuo H 

PROVIDER: S-EPMC12464029 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature