Tracking prodromal Parkinson's disease: a five-year follow-up of the PARCAS cohort.

ABSTRACT:

Background

The updated International Parkinson and Movement Disorders Society (MDS) research criteria for prodromal Parkinson's disease (pPD) enable pPD probability assessment. In the PARkinson's disease associated Colonic Alpha-Synuclein biomarker (PARCAS) study, we previously identified 12 possible (7.5%) and 10 probable (6.3%) pPD cases among 160 elderly individuals undergoing colonoscopy at baseline.

Objective

To apply MDS pPD criteria in the PARCAS cohort at five-year follow-up (FU), evaluating pPD detection, longitudinal stability, and conversion rates to Parkinson's disease (PD) or other neurodegenerative diseases.

Methods

We assessed all risk and prodromal markers except genetic testing; DaTscan and polysomnography (PSG)-confirmed idiopathic REM sleep behavior

SUBMITTER: Kulcsarova K 

PROVIDER: S-EPMC12464032 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature