Apraxic deficits predict general cognitive impairment in patients with biomarker-verified Alzheimer's pathology.

ABSTRACT: Apraxia represents a core feature of Alzheimer's disease (AD), a neurodegenerative disorder characterised by the accumulation of β-amyloid plaques and tau deposition. However, systematic descriptions of apraxic deficits in AD patients remain scarce. Here, we comprehensively investigate apraxia profiles and their link with cognitive impairment in patients with biomarker-verified Alzheimer's pathology. We characterised the frequency and patterns of apraxic deficits in patients with biomarker-verified Alzheimer's pathology using a battery of standardised apraxia tests. Demographic variables and apraxia scores were related to patients' general cognitive impairment using hierarchical regression analysis. Apraxic deficits were found in 67% of patients with biomarker-verified Alzheimer's patholog

SUBMITTER: Schmidt CC 

PROVIDER: S-EPMC12464036 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature