Evaluating clinical response to primary endocrine therapy in elderly breast cancer patients in routine practice.

ABSTRACT:

Purpose

Endocrine therapy (ET) can be used as a definitive treatment in frail and elderly breast cancer patients who are unwilling or deemed unfit to undergo surgical treatment. This study evaluated the clinical response to ET as primary treatment in elderly patients with non-metastatic, oestrogen receptor (ER) positive breast cancer, by evaluating its effectiveness over time.

Methods

Elderly patients (≥ 70 years) with ER-positive breast cancer who had been treated with ET as primary treatment between 2008 and 2015 in two Dutch hospitals were identified through the Netherlands Cancer Registry. The primary outcome was the objectively measured clinical response at various time intervals after initiation of ET.

Results

Out of 122 patients (median age, 86 years), 100 (82%

SUBMITTER: Dinger TL 

PROVIDER: S-EPMC12464097 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature