Risky decision-making in dementia: Exploring neural correlates and related clinical symptoms.

ABSTRACT:

Background

Appropriately balancing potential risks versus rewards is important for affective decision-making in everyday life. Impaired affective decision-making on risk-taking tasks has been reported in individuals with dementia, but the neural correlates of such deficits, and whether they relate to neuropsychiatric symptoms, such as disinhibition and apathy, have not been directly examined.

Methods

Forty-one behavioural-variant frontotemporal dementia (bvFTD), 28 Alzheimer's disease (AD) patients and 42 healthy controls completed the Balloon Analogue Risk Task (BART), which assessed their ability to weigh risks versus rewards to maximise monetary earnings. Informant-reported measures of disinhibition and apathy were completed. All participants underwent structural magnetic

SUBMITTER: Day ME 

PROVIDER: S-EPMC12464114 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature