Role of DENN Domain-Containing Protein 5b (dennd5b) during early embryonic development of zebrafish.

ABSTRACT: Prior studies on non-canonical Wnt signaling have established Dishevelled Associated Activator of Morphogenesis 1 (Daam1) as a crucial link in cell movements by cytoskeletal rearrangement. Overexpression or depletion of Daam1 blocks gastrulation in Xenopus embryos and results in phenotype characteristic of spina bifida. A yeast two-hybrid screen has been performed to further identify factors required downstream of Daam1. Among many, DENN (Differentially Expressed in Normal versus Neoplastic cells) domain-containing protein 5 (Dennd5A) is identified as a binding partner of Daam1. In zebrafish, dennd5a and dennd5b are human orthologues of DENND5A and DENND5B. Until now, no data on zebrafish dennd5b's expression or function is available. This current study elucidates the expression and functi

SUBMITTER: Mendoza A 

PROVIDER: S-EPMC12464149 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature