Role of glycolysis related genes in the pathogenesis of hemorrhoids and immune cell infiltration analysis.

ABSTRACT: Hemorrhoids are a prevalent condition affecting the anorectal area. Recent studies have highlighted glycolysis as a crucial metabolic pathway in numerous diseases. However, systematic studies exploring the distinct functions of the seven glycolysis-related genes (GRGs) during hemorrhoid development are limited. This investigation sought to elucidate the function of GRGs in hemorrhoid development and their correlation with immune cell infiltration. Using bioinformatics methodologies, we performed differential expression analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, gene set enrichment analysis (GSEA), establishment of protein-protein interaction (PPI) networks, and analysis of immune infiltration. We identified 34 glycolysis-related dif

SUBMITTER: Li P 

PROVIDER: S-EPMC12464167 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature