Tabersonine inhibits inflammation and apoptosis through the JAK1/STAT3 signaling pathway to alleviate LPS-induced acute lung injury.

ABSTRACT: Tabersonine (Tab) holds potential therapeutic value for acute lung injury (ALI), but its mechanism remains unraveled. In order to delve into the mechanism of Tab in ALI treatment, our research group initially conducted a network pharmacology prediction. The GSE225664 single-cell transcriptome data set concerning ALI was downloaded from the GEO database. Differential expression analysis combined with weighted gene co-expression network analysis were carried out for identifying ALI-related genes. The drug-related database was employed for the prediction of Tab targets. 28 ALI-Tab targets were predicted through network pharmacology. Core target identification, KEGG pathway enrichment analysis, and molecular docking revealed that Janus kinase 1 (JAK1) is the potential target and the JAK-signal

SUBMITTER: Ji M 

PROVIDER: S-EPMC12464169 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature