Multifunctional poly (lactic acid)/vanillin coatings on drug loaded titanium nanotube arrays for improved biocompatibility, corrosion resistance, and antibacterial characteristics.

ABSTRACT: Developing novel and effective methods for producing multifunctional polymeric bioactive coatings with controlled drug release has become a top priority for the scientific community. In the current study, a novel controlled drug delivery system was developed on the surface of a Ti alloy implant using a biodegradable polymer matrix composed of synthetic polymer (Polylactic acid (PLA)), biodegradable polymer (Vanillin (Van)), and antibiotic drug (Gentamycin (GM)) loaded Ti nanotubes (TNT). The chemical structure, microstructure, and surface properties of the TNT and coated surfaces were investigated using SEM/EDS, TEM, XRD, FT-IR, and water contact angle measurements. The obtained results revealed that the PLA/1Van/GM/TNT coatings released GM from the PLA/Van matrix at a linear rate and with

SUBMITTER: Kumar AM 

PROVIDER: S-EPMC12464193 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature