Association between exacerbation history and airway bacterial community assessed by extended bacterial culture and sequencing approaches in stable COPD.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by chronic respiratory symptoms due to abnormalities of the airways and/or alveoli that cause airflow obstruction. It is a leading cause of death worldwide. While alterations in airway bacterial community have been linked to exacerbation frequency, the underlying mechanisms remain unclear. We aimed to characterize associations between airway bacterial community structure and exacerbation history in stable COPD patients and to identify candidate microbial markers that could assist in risk assessment for the clinical management of COPD patients. Sixty-two stable COPD patients were enrolled and categorized into two groups based on their exacerbation history: low risk (LR) and high risk (HR) of exacerb

SUBMITTER: Lecomte-Thenot Q 

PROVIDER: S-EPMC12464265 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature