Optimizing the radiation dose in a murine model of breast implant capsular fibrosis.

ABSTRACT: Breast implant capsular contracture (CC) is the leading complication following reconstructive breast surgery, especially in breast cancer patients who undergo radiotherapy after reconstruction surgery. The exact pathophysiology of this complication is unclear with limited treatment options and high-quality research models are greatly needed. Here, we aimed to determine the optimal protocol to create an easily reproducible murine model that recapitulates the effects of radiotherapy following breast implantation. We implanted smooth mini silicone breast implants into a dorsal subcutaneous pocket of 8-week-old, female C57Bl/6 mice. Then, we immediately applied a directed dose of 10-Gy (N = 11), and 15-Gy (N = 11) slit-beam radiation to the implanted area along with non-irradiated mice (N = 11

SUBMITTER: Govrin-Yehudain O 

PROVIDER: S-EPMC12464307 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature