Anatomical mapping of GFAP-immunoreactive astrocytes in the tree shrew brain.

ABSTRACT: Astrocytes are associated with varying brain size between rodents and primates. As a close evolutionary relative of primates, the tree shrew ( Tupaia belangeri) provides a valuable comparative model for investigating glial architecture. However, the anatomical distribution and morphological characteristics of astrocytes in the tree shrew brain remain poorly characterized. In this study, glial fibrillary acidic protein (GFAP) immunofluorescence was employed to systematically examine the spatial distribution and morphology of astrocytes in the whole brain of tree shrews. Notably, GFAP-immunoreactive (ir) astrocytes were detected throughout the telencephalon, diencephalon, mesencephalon, metencephalon, and myelencephalon. Distinct laminar distribution was evident in regions such as the

SUBMITTER: Wang YT 

PROVIDER: S-EPMC12464369 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature