Phenotypic, transcriptomic, and genomic analyses reveal the spatiotemporal patterns and associated genes of coarse hair density in goats.

ABSTRACT: The genetic regulation of hair density in animals remains poorly understood. The Dazu black goat, characterized by its black coarse hair and white skin, provides a unique model for dissecting coarse hair density (CHD). Using high-resolution micro-camera imaging, this study analyzed 905 skin images, 33 skin transcriptomes, 272 whole-genome sequences, and 182 downloaded transcriptomes. Morphological assessment from juvenile to adult stages revealed the thickening of hair shafts accompanied by a progressive decline in density, largely attributable to rapid surface expansion of the trunk skin. Transcriptomic comparison between high- and low-CHD individuals identified 572 differentially expressed genes (DEGs). A genome-wide association study detected 25 significant single nucleotide polymorphis

SUBMITTER: Zhang JP 

PROVIDER: S-EPMC12464370 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature