Neural epidermal growth factor-like 1 expression predicts end-stage renal disease in phospholipase A2 receptor-negative membranous nephropathy: A retrospective cohort stratified by systemic lupus erythematosus.

ABSTRACT: BackgroundNeural epidermal growth factor-like 1 protein has emerged as a significant antigen in membranous nephropathy, an important cause of nephrotic syndrome in adults. However, the prognosis of neural epidermal growth factor-like 1-associated membranous nephropathy remains limited and requires further exploration.MethodsA Chinese retrospective cohort of 446 patients diagnosed with membranous nephropathy on renal biopsy was categorized into phospholipase A2 receptor-associated (n = 358) and phospholipase A2 receptor-negative (n = 88) membranous nephropathy groups. The phospholipase A2 receptor-negative group was subjected to neural epidermal growth factor-like 1 fluorescence staining. Multivariate regression analyses, stratified analyses, and Kaplan-Meier analyses were used to explore t

SUBMITTER: Rao Q 

PROVIDER: S-EPMC12464392 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature