<i>Siegesbeckia Glabrescens</i> Extract Ameliorates Immobilization-Induced Muscle Atrophy by Regulating the Akt/mTOR/FoxO3a Signaling Pathways in Mice.

ABSTRACT: Siegesbeckia glabrescens, traditionally used for its anti-inflammatory properties and potential musculoskeletal benefits. In the present study, we investigated whether a standardized hot water extract of S. glabrescens (SGE), rich in the bioactive compound kirenol, could mitigate muscle atrophy caused by immobilization in a mouse model. Male C57BL/6J mice underwent hindlimb immobilization for 1 week to induce muscle atrophy, followed by 1 week of daily oral treatments with either saline or SGE (150 or 300 mg/kg/day). SGE significantly prevented the decline in muscle mass (5.1%-22.7%, p < 0.05), strength (26.0%-36.6%, p < 0.05), volume, and muscle fiber cross-sectional area (21.6%-29.8%, p < 0.05) caused by immobilization. In the tibialis anterior muscle,

SUBMITTER: Han S 

PROVIDER: S-EPMC12464453 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature