Factors Influencing 25-Year Survival in Pediatric Liver Transplant Recipients.

ABSTRACT:

Background

This study assesses the impact of cholestatic liver disease, including biliary atresia, on 25-year survival post-transplantation and additional factors influencing long-term outcomes after pediatric liver transplantation.

Methods

We conducted a retrospective analysis of pediatric liver transplant recipients (1987-1998) using de-identified data from the OPTN 2023 Liver Database. After exclusions for multi-organ transplants (n = 222), prior transplants (n = 2256), and deaths within 1 year (n = 526), 2429 patients remained, including 645 with cholestatic disease. Univariate and multivariate analyses identified factors associated with 25-year survival.

Results

A primary diagnosis of cholestatic disease was associated with improved 25-year survival (OR: 0.67, p 

SUBMITTER: Wortham G 

PROVIDER: S-EPMC12464467 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature