Epidemiology of autonomic dysfunction in Parkinson's disease (Review).

ABSTRACT: Although autonomic dysfunction symptoms are commonly reported by patients with Parkinson's disease (PD) (70-90%), they are frequently under-recognized. Dysautonomia often precedes motor symptoms and can affect the quality of life (QoL) of patients with PD. The present review provides a summary of evidence on prevalence patterns, risk factors and clinical presentations from organ systems related to autonomic dysfunction. Cardiovascular symptoms include orthostatic hypotension (30-50%), supine hypertension (34-50%) and non-dipping patterns of blood pressure (83-88%). Constipation is commonly observed during the prodromal period (60%), and is observed in up to 100% of patients with PD. Genitourinary (89%) and sexual dysfunctions (52-75%) are common, although under-reported. An older age, male

SUBMITTER: Rissardo JP 

PROVIDER: S-EPMC12464526 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature