Can auditory processing dysfunction indicate early cognitive decline?

ABSTRACT:

Introduction

Central auditory processing (CAP) is crucial for speech perception and is also fundamental for cognitive function. This study investigated whether gap detection threshold (GDT) could serve as an early marker for identifying individuals with cognitive impairment (CI) at high risk of dementia.

Methods

Sixty-four older adults underwent peripheral auditory, cognitive, and CAP assessments. Machine learning and resting state electroencephalography (EEG)/event-related potential (ERP) analyses explored predictors and neural correlates of CI.

Results

GDT was significantly higher in those with CI (mean ± standard deviation: 8.25 ± 6.14 versus 5.98 ± 3.44 ms, respectively, p = 0.034), and negatively correlated with cognitive test scores (e.g., Addenbrooke's C

SUBMITTER: Ma X 

PROVIDER: S-EPMC12464561 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature