Resveratrol Improves Cognitive Function in Sleep-Deprived Mice by Inhibiting p38 MAPK Signaling Pathway.

ABSTRACT: Resveratrol (RES) is a naturally occurring polyphenolic compound possessing neuroprotective properties. This study aims to examine the potential of RES to ameliorate sleep disorder-associated cognitive deficits induced by sleep deprivation (SD) in mice. Adult male C57/BL6 mice were subjected to SD for 72 h, and RES were administrated. Behavioral tests were performed to quantify the cognitive behaviors. RNA-sequencing coupled with bioinformatic analysis was executed to examine gene expression patterns in the hippocampus. Furthermore, the levels of apoptosis and synaptic plasticity were measured by western blotting and histological staining techniques, including the TUNEL and Nissl methods. Morris water maze, novel object recognition and open field tests demonstrated that RES swiftly attenua

SUBMITTER: Tang Y 

PROVIDER: S-EPMC12464565 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature