Astaxanthin Alleviates Lead-Induced Toxicity by Restoring Hepatic and Gut-Liver Axis Homeostasis Through Multidimensional Metabolic and Antioxidative Pathways.

ABSTRACT: Lead (Pb) poisoning is a major public health concern of environmental origin in the world. It is essential to develop effective ways such as utilizing natural products as therapeutic agents for prevention and therapy of Pb-induced diseases. This study explores the effects and underlying mechanisms of astaxanthin (ATX), a natural compound with potent antioxidant properties, in alleviating Pb-induced toxicity in model mice. Supplementation with ATX significantly ameliorated lead-induced physiological and biochemical disruptions, including weight loss, hepatic and renal damage, and metabolic imbalances. Metabolomic and transcriptomic analyses revealed that ATX played a positive role in improving redox homeostasis, regulating lipid, amino acid, and nucleotide metabolism, and activating critica

SUBMITTER: Du Z 

PROVIDER: S-EPMC12464569 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature