Adipose tissue macrophage-derived miR-690 modulates adipocyte precursor cell maintenance and adipogenesis.

ABSTRACT: Obesity is intricately linked to various metabolic diseases; however, some individuals maintain metabolic health despite being classified as obese. A critical factor underlying this paradox is the expansion of white adipose tissue (WAT), which can occur through two mechanisms: hypertrophy (the enlargement of existing fat cells) and hyperplasia (the formation of new fat cells from adipocyte precursor cells, or APCs). Hyperplasia is regarded as a healthier mode of WAT expansion, as it tends to reduce inflammation and protect against insulin resistance. Thus, interventions that promote hyperplasia over hypertrophy could improve metabolic health in obese individuals. In this study, we investigate the role of microRNA-690 (miR-690), an anti-inflammatory and insulin-sensitizing molecule, in main

SUBMITTER: Cunha E Rocha K 

PROVIDER: S-EPMC12464593 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature