Bioinspired Smart Nanogels for Rapid Blue Laser-Activated Hemostasis in Gastrointestinal Bleeding.

ABSTRACT: Gastrointestinal bleeding (GIB) is a critical condition that requires rapid and effective intervention. Although thrombin is a widely used hemostatic agent, its efficacy is limited in the harsh environment of the digestive tract, especially in patients with chronic liver disease or coagulation disorders. Current treatment techniques often fall short, particularly when faced with severe blood loss and coagulation challenges. Here, a novel solution: waxberry-inspired smart nanogels that offer a cost-effective, highly efficient, and mechanically stable approach for local hemostasis is presented. Drawing inspiration from the microfibrous structures of waxberry, a waxberry-like nano-silica with a radially fibrous structure is synthesized for effective thrombin loading and release upon emergency

SUBMITTER: Dan R 

PROVIDER: S-EPMC12464633 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature